IgA and neutralizing antibodies to influenza a virus in human milk: a randomized trial of antenatal influenza immunization.

ABSTRACT:

Background

Antenatal immunization of mothers with influenza vaccine increases serum antibodies and reduces the rates of influenza illness in mothers and their infants. We report the effect of antenatal immunization on the levels of specific anti-influenza IgA levels in human breast milk. (ClinicalTrials.gov identifier NCT00142389; http://clinicaltrials.gov/ct2/show/NCT00142389).

Methods and findings

The Mother's Gift study was a prospective, blinded, randomized controlled trial that assigned 340 pregnant Bangladeshi mothers to receive either trivalent inactivated influenza vaccine, or 23-valent pneumococcal polysaccharide vaccine during the third trimester. We evaluated breast milk at birth, 6 weeks, 6 months, and 12 months, and serum at 10 weeks and 12 months. Milk and seru

SUBMITTER: Schlaudecker EP 

PROVIDER: S-EPMC3743877 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature