Meta-analysis of genetic programs between idiopathic pulmonary fibrosis and sarcoidosis.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) and pulmonary sarcoidosis are typical interstitial lung diseases with unknown etiology that cause lethal lung damages. There are notable differences between these two pulmonary disorders, although they do share some similarities. Gene expression profiles have been reported independently, but differences on the transcriptional level between these two entities have not been investigated.

Methods/results

All expression data of lung tissue samples for IPF and sarcoidosis were from published datasets in the Gene Expression Omnibus (GEO) repository. After cross platform normalization, the merged sample data were grouped together and were subjected to statistical analysis for finding discriminate genes. Gene enrichments with their corr

SUBMITTER: Leng D 

PROVIDER: S-EPMC3743918 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature