Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis.

ABSTRACT: Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing of Leptospira interrogans serovar Copenhageni and comparative analysis with the available Leptospira interrogans serovar Lai genome reveal that despite overall genetic similarity there are significant structural differences, including a large chromosomal inversion and extensive variation in the number and distribution of insertion sequence elements. Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis. A broad array of transcriptional regulation p

SUBMITTER: Nascimento AL 

PROVIDER: S-EPMC374407 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature