Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo.

ABSTRACT: Cell migration is an important biological process which has been intensively studied in the past decades. Numerous techniques, mainly involving two-dimensional cell culture systems, have contributed to dissecting the essential mechanisms underlying this process. However, the development of three-dimensional cell culture and in vivo systems has shown some differences with what was previously believed to be well-established cell migration mechanisms, suggesting that two-dimensional cell motility would be a poor predictor of in vivo behaviour. Drosophila is a widely recognized model organism to study developmental and homeostatic processes and has been widely used to investigate cell migration. Here, we focus on the migration of small groups of pupal hemocytes that accumulate during larval st

SUBMITTER: Moreira CG 

PROVIDER: S-EPMC3744071 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature