Where are we on worms?

ABSTRACT:

Purpose of review

There is something about living in an industrialized country that dramatically increases the risk of acquiring inflammatory bowel disease (IBD). Loss of routine exposure to parasitic worms (helminths), due to modern highly hygienic life styles, likely contributes to this risk. This article reviews current understanding on how helminths influence intestinal inflammation and mucosal immune responses.

Recent findings

IBD emerges in populations as regions develop socioeconomically and lose exposure to previously ubiquitous helminthic infections. Helminthic infections provided strong selective pressure for the dissemination of gene variants, many of which predispose to development of IBD. In animal models of IBD, helminth colonization suppresses intestinal infla

SUBMITTER: Elliott DE 

PROVIDER: S-EPMC3744105 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature