Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.

ABSTRACT:

Background

Current chemotherapy for Chagas disease is unsatisfactory due to its limited efficacy, particularly in the chronic phase, with frequent side effects that can lead to treatment discontinuation. Combined therapy is envisioned as an ideal approach since it may improve treatment efficacy whilst decreasing toxicity and the likelihood of resistance development. We evaluated the efficacy of posaconazole in combination with benznidazole on Trypanosoma cruzi infection in vivo.

Methods and findings

Benznidazole and posaconazole were administered individually or in combination in an experimental acute murine infection model. Using a rapid treatment protocol for 7 days, the combined treatments were more efficacious in reducing parasitemia levels than the drugs given alone, wi

SUBMITTER: Diniz Lde F 

PROVIDER: S-EPMC3744424 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature