Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.

ABSTRACT: In neurons, the timely and accurate expression of genes in response to synaptic activity relies on the interplay between epigenetic modifications of histones, recruitment of regulatory proteins to chromatin and changes to nuclear structure. To identify genes and regulatory elements responsive to synaptic activation in vivo, we performed a genome-wide ChIPseq analysis of acetylated histone H3 using somatosensory cortex of mice exposed to novel enriched environmental (NEE) conditions. We discovered that Short Interspersed Elements (SINEs) located distal to promoters of activity-dependent genes became acetylated following exposure to NEE and were bound by the general transcription factor TFIIIC. Importantly, under depolarizing conditions, inducible genes relocated to transcription factories (

SUBMITTER: Crepaldi L 

PROVIDER: S-EPMC3744447 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature