An exploration of heat tolerance in mice utilizing mRNA and microRNA expression analysis.

ABSTRACT:

Background

Individuals who rapidly develop hyperthermia during heat exposure (heat-intolerant) are vulnerable to heat associated illness and injury. We recently reported that heat intolerant mice exhibit complex alterations in stress proteins in response to heat exposure. In the present study, we further explored the role of genes and molecular networks associated with heat tolerance in mice.

Methodology

Heat-induced physiological and biochemical changes were assessed to determine heat tolerance levels in mice. We performed RNA and microRNA expression profiling on mouse gastrocnemius muscle tissue samples to determine novel biological pathways associated with heat tolerance.

Principal findings

Mice (n = 18) were assigned to heat-tolerant (TOL) and heat-intolerant (INT

SUBMITTER: Islam A 

PROVIDER: S-EPMC3744453 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature