Hydrogel-coated microfluidic channels for cardiomyocyte culture.

ABSTRACT: The research areas of tissue engineering and drug development have displayed increased interest in organ-on-a-chip studies, in which physiologically or pathologically relevant tissues can be engineered to test pharmaceutical candidates. Microfluidic technologies enable the control of the cellular microenvironment for these applications through the topography, size, and elastic properties of the microscale cell culture environment, while delivering nutrients and chemical cues to the cells through continuous media perfusion. Traditional materials used in the fabrication of microfluidic devices, such as poly(dimethylsiloxane) (PDMS), offer high fidelity and high feature resolution, but do not facilitate cell attachment. To overcome this challenge, we have developed a method for coating microf

SUBMITTER: Annabi N 

PROVIDER: S-EPMC3744594 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature