Impact of DNA damaging agents on genome-wide transcriptional profiles in two marine Synechococcus species.

ABSTRACT: Marine microorganisms, particularly those residing in coastal areas, may come in contact with any number of chemicals of environmental or xenobiotic origin. The sensitivity and response of marine cyanobacteria to such chemicals is, at present, poorly understood. We have looked at the transcriptional response of well characterized Synechococcus open ocean (WH8102) and coastal (CC9311) isolates to two DNA damaging agents, mitomycin C and ethidium bromide, using whole-genome expression microarrays. The coastal strain showed differential regulation of a larger proportion of its genome following "shock" treatment with each agent. Many of the orthologous genes in these strains, including those encoding sensor kinases, showed different transcriptional responses, with the CC9311 genes more likely

SUBMITTER: Tetu SG 

PROVIDER: S-EPMC3744912 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature