Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery.

ABSTRACT:

Objectives

Post-cardiac surgery vasoplegia is a common complication of cardiac surgery, characterized by profound loss of systemic vascular resistance. This results in severe hypotension, high cardiac output and metabolic acidosis reflecting inadequate tissue perfusion. The pathophysiological mechanisms underlying this syndrome remain unknown. We hypothesized that this vasoplegia reflects endothelial dysfunction, either as pre-existing condition or as a consequence of the surgical procedure.

Methods

To examine these mechanisms, six established and distinct markers of endothelial cell activation were measured pre- and perioperatively in patients undergoing mitral valve surgery. Arterial (radial artery) and myocardial venous blood samples (coronary sinus) were collected simult

SUBMITTER: Kortekaas KA 

PROVIDER: S-EPMC3745151 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature