Vagal blocking improves glycemic control and elevated blood pressure in obese subjects with type 2 diabetes mellitus.

ABSTRACT:

Background

An active device that downregulates abdominal vagal signalling has resulted in significant weight loss in feasibility studies.

Objective

To prospectively evaluate the effect of intermittent vagal blocking (VBLOC) on weight loss, glycemic control, and blood pressure (BP) in obese subjects with DM2.

Methods

Twenty-eight subjects were implanted with a VBLOC device (Maestro Rechargeable System) at 5 centers in an open-label study. Effects on weight loss, HbA1c, fasting blood glucose, and BP were evaluated at 1 week to 12 months.

Results

26 subjects (17 females/9 males, 51 ± 2 years, BMI 37 ± 1 kg/m(2), mean ± SEM) completed 12 months followup. One serious adverse event (pain at implant site) was easily resolved. At 1 week and 12 months, mean excess weigh

SUBMITTER: Shikora S 

PROVIDER: S-EPMC3745954 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature