Computer aided screening of Accacia nilotica phytochemicals against HCV NS3/4a.

ABSTRACT:

Background

HCV has become a leading cause of liver cirrhosis and hepatocellular carcinoma and is a major health concern worldwide. To date, there is no vaccine available in the market to tackle this disease, therefore there is a strong need to develop antiviral compounds that can target all genotypes of HCV with the same efficiency. Medicinal plants have low cost and are less toxic therefore, extracts of medicinal plants can serve as important antiviral agents against HCV. This study was designed to screen phytochemicals of Accacia nilotica to find a potent drug candidate that can inhibit HCV infection effectively.

Results

Docking of NS3/4A protease and Flavonoids of Accacia nilotica revealed that most of the flavonoids bound deeply with the active site of NS3/4A protease. C

SUBMITTER: Khan M 

PROVIDER: S-EPMC3746092 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature