Genetics can contribute to the prognosis of Brugada syndrome: a pilot model for risk stratification.

ABSTRACT: Brugada syndrome is an inherited arrhythmogenic disorder leading to sudden death predominantly in the 3-4 decade. To date the only reliable treatment is the implantation of a cardioverter defibrillator; however, better criteria for risk stratification are needed, especially for asymptomatic subjects. Brugada syndrome genetic bases have been only partially understood, accounting for <30% of patients, and have been poorly correlated with prognosis, preventing inclusion of genetic data in current guidelines. We designed an observational study to identify genetic markers for risk stratification of Brugada patients by exploratory statistical analysis. The presence of genetic variants, identified by SCN5A gene analysis and genotyping of 73 candidate polymorphisms, was correlated with the occurre

SUBMITTER: Sommariva E 

PROVIDER: S-EPMC3746265 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature