A dual Lewis base activation strategy for enantioselective carbene-catalyzed annulations.

ABSTRACT: A dual activation strategy integrating N-heterocyclic carbene (NHC) catalysis and a second Lewis base has been developed. NHC-bound homoenolate equivalents derived from α,β-unsaturated aldehydes combine with transient reactive o-quinone methides in an enantioselective formal [4 + 3] fashion to access 2-benzoxopinones. The overall approach provides a general blueprint for the integration of carbene catalysis with additional Lewis base activation modes.

SUBMITTER: Izquierdo J 

PROVIDER: S-EPMC3746556 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature