Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons.

ABSTRACT:

Objective

To determine the effect of inhibiting aromatase activity on endometrial lesion growth and aromatase expression in a baboon model of induced endometriosis.

Design

Prospective study.

Setting

Primate research institute.

Animal(s)

Sixteen olive baboons.

Intervention(s)

Sixteen olive baboons with induced endometriosis were examined with laparoscopy 10 months after disease inoculation. Animals in group 1 (n = 10) were treated with 1.25 mg/d of the aromatase inhibitor (AI) letrozole, and animals in group 2 (n = 6) were given a placebo for a total of 6 months.

Main outcome measure(s)

Total number of endometriotic lesions, morphology, and volume of lesions, as well as semiquantitative reverse transcription-polymerase chain reaction and quantitati

SUBMITTER: Langoi D 

PROVIDER: S-EPMC3746767 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature