Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity.

ABSTRACT: Vaccines are among the most effective approaches to prevent and control many infectious diseases. Because of safety and reproducibility concerns, whole-cell vaccines (WCVs), made from live or killed microorganisms and including hundreds of antigenic components, have been mostly replaced by acellular or subunit vaccines composed of well-defined, purified antigen components. The efficacy of acellular vaccines is inferior to that of WCVs, however, for two major reasons: limited antigen diversity and reduced immunogenicity, especially in a lack of activation of antigen-specific T-cell immunity, which plays an important role in protection against mucosal and intracellular pathogens. Here we present the multiple antigen-presenting system (MAPS), which enables the creation of a macromolecular com

SUBMITTER: Zhang F 

PROVIDER: S-EPMC3746895 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature