Synthesis and biological evaluation of novel sulfonanilide compounds as antiproliferative agents for breast cancer.

ABSTRACT: Combinatorial chemistry approaches facilitate drug discovery processes and result in structural modifications of lead compounds that enhance pharmacological activity, improve pharmacokinetic properties, or reduce unwanted side effects. Epidemiological and animal model studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) can act as chemopreventive agents. The cyclooxygenase-2 (COX-2) inhibitor nimesulide shows anticancer effects in several cancer cell lines via COX-2-dependent and -independent mechanisms. The molecular structure of nimesulide was used as a starting scaffold to design novel sulfonanilide analogs and examine the structural features that contribute to this anticancer effect. A systematic combinatorial chemical approach was used to generate diversely substi

SUBMITTER: Su B 

PROVIDER: S-EPMC3746990 | biostudies-literature | 2008 May-Jun

REPOSITORIES: biostudies-literature