Differential DNA methylation regions in cytokine and transcription factor genomic loci associate with childhood physical aggression.

ABSTRACT:

Background

Animal and human studies suggest that inflammation is associated with behavioral disorders including aggression. We have recently shown that physical aggression of boys during childhood is strongly associated with reduced plasma levels of cytokines IL-1α, IL-4, IL-6, IL-8 and IL-10, later in early adulthood. This study tests the hypothesis that there is an association between differential DNA methylation regions in cytokine genes in T cells and monocytes DNA in adult subjects and a trajectory of physical aggression from childhood to adolescence.

Methodology/principal findings

We compared the methylation profiles of the entire genomic loci encompassing the IL-1α, IL-6, IL-4, IL-10 and IL-8 and three of their regulatory transcription factors (TF) NFkB1, NFAT5 and ST

SUBMITTER: Provencal N 

PROVIDER: S-EPMC3747262 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature