Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit.

ABSTRACT: Pandemic outbreaks of highly virulent influenza strains can cause widespread morbidity and mortality in human populations worldwide. In the United States alone, an average of 41,400 deaths and 1.86 million hospitalizations are caused by influenza virus infection each year (1). Point mutations in the polymerase basic protein 2 subunit (PB2) have been linked to the adaptation of the viral infection in humans (2). Findings from such studies have revealed the biological significance of PB2 as a virulence factor, thus highlighting its potential as an antiviral drug target. The structural genomics program put forth by the National Institute of Allergy and Infectious Disease (NIAID) provides funding to Emerald Bio and three other Pacific Northwest institutions that together make up the Seattle St

SUBMITTER: Armour BL 

PROVIDER: S-EPMC3747311 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature