Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury.

ABSTRACT:

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Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and network connections mediating acute lung injury, using severe acute respiratory syndrome coronavirus (SARS-CoV) as a model pathogen. We utilized a time course of matched virologic, pathological, and transcriptomic data within a novel methodological framework that can detect pathway enrichment among key highly connected network genes. This unbiased approach produced a high-priority list of 4 genes in one pathway out of over 3,500 genes that were differentially expressed following SAR

SUBMITTER: Gralinski LE 

PROVIDER: S-EPMC3747576 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature