Livestock origin for a human pandemic clone of community-associated methicillin-resistant Staphylococcus aureus.

ABSTRACT:

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The importance of livestock as a source of bacterial pathogens with the potential for epidemic spread in human populations is unclear. In recent years, there has been a global increase in community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections of healthy humans, but an understanding of the different evolutionary origins of CA-MRSA clones and the basis for their recent expansion is lacking. Here, using a high-resolution phylogenetic approach, we report the discovery of two emergent clones of human epidemic CA-MRSA which resulted from independent livestock-to-human host jumps by the major bovine S. aureus complex, CC97. Of note, one of the new clones was isolated from human infections on four continents, demonstrating its global dissemination

SUBMITTER: Spoor LE 

PROVIDER: S-EPMC3747577 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature