1H NMR based targeted metabolite profiling for understanding the complex relationship connecting oxidative stress with endometriosis.

ABSTRACT: Accumulating evidence indicates the active role of oxidative stress in the development of endometriosis; however, the mechanism of reactive oxygen species generation is poorly understood. Metabonomics/metabolomics is a scientific discipline that can be used to study changes in metabolite ensembles associated with disease pathophysiology. The present study focuses on the use of proton nuclear magnetic resonance spectroscopy based targeted metabolite profiling approach to explore dysregulation in metabolites expression in women with endometriosis. Further, association of oxidative stress with the metabolite ensembles, if any, is investigated. Using multivariate statistics, partial least square discriminant analysis model was generated which could classify endometriosis patients with sensitiv

SUBMITTER: Jana SK 

PROVIDER: S-EPMC3747613 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature