MUC5B promoter polymorphism and interstitial lung abnormalities.

ABSTRACT:

Background

A common promoter polymorphism (rs35705950) in MUC5B, the gene encoding mucin 5B, is associated with idiopathic pulmonary fibrosis. It is not known whether this polymorphism is associated with interstitial lung disease in the general population.

Methods

We performed a blinded assessment of interstitial lung abnormalities detected in 2633 participants in the Framingham Heart Study by means of volumetric chest computed tomography (CT). We evaluated the relationship between the abnormalities and the genotype at the rs35705950 locus.

Results

Of the 2633 chest CT scans that were evaluated, interstitial lung abnormalities were present in 177 (7%). Participants with such abnormalities were more likely to have shortness of breath and chronic cough and reduced measu

SUBMITTER: Hunninghake GM 

PROVIDER: S-EPMC3747636 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature