Selection of the most informative individuals from families with multiple siblings for association studies.

ABSTRACT: Association analyses may follow an initial linkage analysis for mapping and identifying genes underlying complex quantitative traits and may be conducted on unrelated subsets of individuals where only one member of a family is included. We evaluate two methods to select one sibling per sibship when multiple siblings are available: (1) one sibling with the most extreme trait value; and (2) one sibling using a combination score statistic based on extreme trait values and identity-by-descent sharing information. We compare the type I error and power. Furthermore, we compare these selection strategies with a strategy that randomly selects one sibling per sibship and with an approach that includes all siblings, using both simulation study and an application to fasting blood glucose in the Frami

SUBMITTER: Liu C 

PROVIDER: S-EPMC3747668 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature