Management of pulmonary arterial hypertension during pregnancy: a retrospective, multicenter experience.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a rare disease with a predilection for young women that is associated with right ventricular failure and premature death. PAH can complicate pregnancy with hemodynamic instability or sudden death during parturition and postpartum. Our aim was to examine the impact of PAH on pregnancy outcomes in the modern era.

Methods

We conducted a retrospective evaluation of pregnant patients with PAH managed between 1999 and 2009 at five US medical centers. Patient demographics, medical therapies, hemodynamic measurements, manner of delivery, anesthetic administration, and outcomes were assessed.

Results

Among 18 patients with PAH, 12 continued pregnancy and six underwent pregnancy termination. Right ventricular systolic pressure

SUBMITTER: Duarte AG 

PROVIDER: S-EPMC3747723 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature