Epilepsy therapy development: technical and methodologic issues in studies with animal models.

ABSTRACT: The search for new treatments for seizures, epilepsies, and their comorbidities faces considerable challenges. This is due in part to gaps in our understanding of the etiology and pathophysiology of most forms of epilepsy. An additional challenge is the difficulty in predicting the efficacy, tolerability, and impact of potential new treatments on epilepsies and comorbidities in humans, using the available resources. Herein we provide a summary of the discussions and proposals of the Working Group 2 as presented in the Joint American Epilepsy Society and International League Against Epilepsy Translational Workshop in London (September 2012). We propose methodologic and reporting practices that will enhance the uniformity, reliability, and reporting of early stage preclinical studies with an

SUBMITTER: Galanopoulou AS 

PROVIDER: S-EPMC3747731 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature