Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor.

ABSTRACT:

Objective

Factor VII-activating protease (FSAP) activates both factor VII and pro-urokinase and inhibits platelet-derived growth factor-BB, thus regulating hemostasis- and remodeling-associated processes in the vasculature. A genetic variant of FSAP (Marburg I polymorphism) results in low enzymatic activity and is associated with an enhanced risk of carotid stenosis and stroke. We postulate that there are additional substrates for FSAP that will help to explain its role in vascular biology and have searched for such a substrate.

Methods and results

Using screening procedures to determine the influence of FSAP on various hemostasis-related processes on endothelial cells, we discovered that FSAP inhibited tissue factor pathway inhibitor (TFPI), a major anticoagulant secreted b

SUBMITTER: Kanse SM 

PROVIDER: S-EPMC3747817 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature