Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis.

ABSTRACT:

Background

Neonatal infections cause a significant proportion of deaths in the first week of life, yet little is known about risk factors and pathways of transmission for early-onset neonatal sepsis globally. We aimed to estimate the risk of neonatal infection (excluding sexually transmitted diseases [STDs] or congenital infections) in the first seven days of life among newborns of mothers with bacterial infection or colonization during the intrapartum period.

Methods and findings

We searched PubMed, Embase, Scopus, Web of Science, Cochrane Library, and the World Health Organization Regional Databases for studies of maternal infection, vertical transmission, and neonatal infection published from January 1, 1960 to March 30, 2013. Studies were included that reported effect me

SUBMITTER: Chan GJ 

PROVIDER: S-EPMC3747995 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature