A locally congenic backcross design in pig: a new regional fine QTL mapping approach miming congenic strains used in mouse.

ABSTRACT:

Background

In previous studies, a major QTL affecting fatness and growth has been mapped to pig chromosome 1q (SSC1q) using Large White - Meishan intercrosses. A higher fat depth and a larger growth rate have been reported for the allele of MS origin. Additionally the LW allele showed partial dominance effects over the MS allele for both traits. In order to refine the QTL mapping interval, advanced backcross generations were produced. Recombinant heterozygous sires were mated to LW sows in order to progeny test the sire segregation of the QTL and refine the QTL localisation. However due to the partial dominance of the LW allele, BC scheme using LW as the receiving population was not optimal.

Results

To overcome the difficulties related to the dominance of the LW QTL allele,

SUBMITTER: Riquet J 

PROVIDER: S-EPMC3748014 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature