Including non-additive genetic effects in Bayesian methods for the prediction of genetic values based on genome-wide markers.

ABSTRACT:

Background

Molecular marker information is a common source to draw inferences about the relationship between genetic and phenotypic variation. Genetic effects are often modelled as additively acting marker allele effects. The true mode of biological action can, of course, be different from this plain assumption. One possibility to better understand the genetic architecture of complex traits is to include intra-locus (dominance) and inter-locus (epistasis) interaction of alleles as well as the additive genetic effects when fitting a model to a trait. Several Bayesian MCMC approaches exist for the genome-wide estimation of genetic effects with high accuracy of genetic value prediction. Including pairwise interaction for thousands of loci would probably go beyond the scope of such a s

SUBMITTER: Wittenburg D 

PROVIDER: S-EPMC3748015 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature