The diverse distribution of risk factors between breast cancer subtypes of ER, PR and HER2: a 10-year retrospective multi-center study in China.

ABSTRACT:

Introduction

Hormone receptors, human epidermal growth factor receptor 2 and some risk factors determine therapies and prognosis of breast cancer. The risk factors distributed differently between patients with receptors. This study aimed to investigate the distribution of risk factors between subtypes of breast cancer by the 3 receptors in Chinese native women with a large sample size.

Methods

The multi-center study analyzed 4211 patient medical records from 1999 to 2008 in 7 regions of China. Data on patients' demographic information, risk factors (menopausal status, parity, body mass index) and receptor statuses were extracted. Breast cancer subtypes included ER (+/-), PR (+/-), HER2 (+/-), 4 ER/PR and 4 molecular subtypes. Wilcoxon and Chi-square tests were used to estima

SUBMITTER: Song Q 

PROVIDER: S-EPMC3748061 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature