Drusen regression is associated with local changes in fundus autofluorescence in intermediate age-related macular degeneration.

ABSTRACT:

Purpose

To investigate the association of spontaneous drusen regression in intermediate age-related macular degeneration (AMD) with changes on fundus photography and fundus autofluorescence (FAF) imaging.

Design

Prospective observational case series.

Methods

Fundus images from 58 eyes (in 58 patients) with intermediate AMD and large drusen were assessed over 2 years for areas of drusen regression that exceeded the area of circle C1 (diameter 125 μm; Age-Related Eye Disease Study grading protocol). Manual segmentation and computer-based image analysis were used to detect and delineate areas of drusen regression. Delineated regions were graded as to their appearance on fundus photographs and FAF images, and changes in FAF signal were graded manually and quantitated usin

SUBMITTER: Toy BC 

PROVIDER: S-EPMC3748172 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature