Combining genome-wide methods to investigate the genetic complexity of courtship song variation in Drosophila melanogaster.

ABSTRACT: Little is currently known about the genetic complexity of quantitative behavioral variation, the types of genes involved, or their effects on intermediate phenotypes. Here, we conduct a genome-wide association study of Drosophila melanogaster courtship song variation using 168 sequenced inbred lines, and fail to find highly significant associations. However, by combining these data with results from a well-powered Evolve and Resequence (E&R) study on the same trait, we provide statistical evidence that some power to associate genotype and phenotype is available. Genes that are significant in both analyses are enriched for expression in the nervous system, and affect neural development and synaptic growth when perturbed. Quantitative complementation at one of these loci, Syntrophin-like 1,

SUBMITTER: Turner TL 

PROVIDER: S-EPMC3748354 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature