Global gene expression analysis of term amniotic fluid cell-free fetal RNA.

ABSTRACT:

Objective

To identify the tissue expression patterns and biological pathways enriched in term amniotic fluid cell-free fetal RNA by comparing functional genomic analyses of term and second-trimester amniotic fluid supernatants.

Methods

This was a prospective whole genome microarray study comparing eight amniotic fluid samples collected from women at term who underwent prelabor cesarean delivery and eight second-trimester amniotic fluid samples from routine amniocenteses. A functional annotation tool was used to compare tissue expression patterns in term and second-trimester samples. Pathways analysis software identified physiologic systems, molecular and cellular functions, and upstream regulators that were significantly overrepresented in term amniotic fluid.

Results

SUBMITTER: Hui L 

PROVIDER: S-EPMC3748378 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature