Association between efavirenz-based compared with nevirapine-based antiretroviral regimens and virological failure in HIV-infected children.

ABSTRACT:

Importance

Worldwide, the nonnucleoside reverse transcriptase inhibitors (NNRTIs) efavirenz and nevirapine are commonly used in first-line antiretroviral regimens in both adults and children with human immunodeficiency virus (HIV) infection. Data on the comparative effectiveness of these medications in children are limited.

Objective

To investigate whether virological failure is more likely among children who initiated 1 or the other NNRTI-based HIV treatment.

Design, setting, and participants

Retrospective cohort study of children (aged 3-16 years) who initiated efavirenz-based (n = 421) or nevirapine-based (n = 383) treatment between April 2002 and January 2011 at a large pediatric HIV care setting in Botswana.

Main outcomes and measures

The primary outcome w

SUBMITTER: Lowenthal ED 

PROVIDER: S-EPMC3748602 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature