Ontology highlight
ABSTRACT:
SUBMITTER: Huang CK
PROVIDER: S-EPMC3748723 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Stem cell research 20130610 2
Gender differences have been described in osteoporosis with females having a higher risk of osteoporosis than males. The differentiation of bone marrow stromal cells (BMSCs) into bone or fat is a critical step for osteoporosis. Here we demonstrated that loss of the androgen receptor (AR) in BMSCs suppressed osteogenesis but promoted adipogenesis. The mechanism dissection studies revealed that AR deficiency suppressed osteogenesis-related genes to inhibit osteoblast differentiation from BMSCs. Kn ...[more]