Detectable signals of episodic risk effects on acute HIV transmission: strategies for analyzing transmission systems using genetic data.

ABSTRACT: Episodic high-risk sexual behavior is common and can have a profound effect on HIV transmission. In a model of HIV transmission among men who have sex with men (MSM), changing the frequency, duration and contact rates of high-risk episodes can take endemic prevalence from zero to 50% and more than double transmissions during acute HIV infection (AHI). Undirected test and treat could be inefficient in the presence of strong episodic risk effects. Partner services approaches that use a variety of control options will be likely to have better effects under these conditions, but the question remains: What data will reveal if a population is experiencing episodic risk effects? HIV sequence data from Montreal reveals genetic clusters whose size distribution stabilizes over time and reflects the

SUBMITTER: Alam SJ 

PROVIDER: S-EPMC3748724 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature