Emerging therapeutic approaches for multipotent mesenchymal stromal cells.

ABSTRACT:

Purpose of review

Multipotent mesenchymal stromal cells (MSCs) are rare cells resident in bone marrow and other organs capable of differentiating into mesodermal lineage tissues. MSCs possess immunomodulatory properties and have extensive capacity for ex-vivo expansion. Early clinical studies demonstrated safety and feasibility of infusing autologous MSCs and suggested a role in enhancing engraftment after hematopoietic cell transplant (HCT). Subsequent pilot studies using allogeneic MSCs showed safety but presented contradictory results regarding efficacy in treating graft-versus-host disease (GVHD).

Recent findings

Larger, phase II allogeneic MSC infusion studies, including cells obtained from haploidentical and third-party donors, showed efficacy in GVHD treatment; howeve

SUBMITTER: Caimi PF 

PROVIDER: S-EPMC3748957 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature