Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model.

ABSTRACT:

Background

Systemic administration of sclerostin neutralizing antibody has led to increased bone formation in animal models of osteoporosis. The purpose of this study was to determine if systemic administration of sclerostin neutralizing antibody could increase the healing response in a critical-sized femoral defect in rats.

Methods

Critical-sized femoral defects were created in Lewis rats, and the rats were randomized into four groups. The sclerostin antibody (Scl-Ab) treatment groups included the continuous Scl-Ab group (twenty-one animals), the early Scl-Ab group (fifteen animals), and the delayed Scl-Ab group (fifteen animals), which received sclerostin antibody (25 mg/kg) twice weekly for weeks 0 through 12; weeks 0 through 2; and weeks 2 through 4; respectively. Twenty

SUBMITTER: Virk MS 

PROVIDER: S-EPMC3748979 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature