Molecular characterization of articular cartilage from young adults with femoroacetabular impingement.

ABSTRACT:

Background

Femoroacetabular impingement is a frequent cause of hip pain and may lead to secondary osteoarthritis, yet little is known about the molecular events linking mechanical hip impingement and articular cartilage degeneration. The first goal of this study was to quantify the expression of inflammatory cytokine and chemokine, matrix-degrading, and extracellular matrix genes in articular cartilage harvested from control hips and hips with femoroacetabular impingement and end-stage osteoarthritis. The second goal was to analyze the relative expression of these genes in articular cartilage harvested at various stages of osteoarthritis.

Methods

Cartilage samples were obtained from thirty-two hips undergoing hip preservation surgery for femoroacetabular impingement or hip a

SUBMITTER: Hashimoto S 

PROVIDER: S-EPMC3748995 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature