Myeloperoxidase polymorphism, menopausal status, and breast cancer risk: an update meta-analysis.

ABSTRACT: Myeloperoxidase (MPO) is a metabolic/oxidative lysosomal enzyme secreted by reactive neutrophils at the sites of inflamed organs and tissues during phagocytosis. MPO has been either directly or indirectly linked to neoplasia, which is a well-established risk factor for many types of cancer. A large number of studies have reported the role of MPO G-463A polymorphism regarding breast-cancer risk. However, the published findings are inconsistent. Therefore, we conducted a meta-analysis to determine more precise estimations for the relationship. Eligible studies were identified by searching several electronic databases for relevant reports published before June 2012. According to the inclusion criteria and exclusion criteria, a total of five eligible studies were included in the pooled analyse

SUBMITTER: Qin X 

PROVIDER: S-EPMC3749128 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature