Failure to improve cigarette smoking abstinence with transdermal selegiline + cognitive behavior therapy.

ABSTRACT:

Aims

To examine the effectiveness of transdermal selegiline for producing cigarette smoking abstinence.

Design

Adult smokers were randomly assigned to receive selegiline transdermal system (STS) or placebo given for 8 weeks. All participants received cognitive behavior therapy (CBT). Follow-ups were conducted at 25 and 52 weeks.

Setting

Community smoking cessation clinic.

Participants

243 adult smokers (> or =18 years of age; > or =10 cigarettes/day).

Measures

Expired-air carbon monoxide confirmed 7-day point prevalence abstinence.

Findings

STS was not superior to placebo. More women than men were abstinent at 52 week follow-up (28% vs 16%, P < 0.05). Behavioral activation (BAS) moderated treatment response (P = 0.01). The survival rate through we

SUBMITTER: Killen JD 

PROVIDER: S-EPMC3749242 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature