Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice.

ABSTRACT:

Background and objective

Supplementation studies of glutamine, arginine, and docosahexaenoic acid (DHA) have established the safety of each of these nutrients in neonates; however, the potential for a more stable and soluble dipeptide, arginyl-glutamine (Arg-Gln) or DHA with anti-inflammatory properties, to exert benefits on hyperoxia-induced intestinal injury has not been investigated. Arg-Gln dipeptide has been shown to prevent retinal damage in a rodent model of oxygen-induced injury. The objective of the present study was to investigate whether Arg-Gln dipeptide or DHA could also attenuate markers of injury and inflammation to the small intestine in this same model.

Methods

Seven-day-old mouse pups were placed with their dams in 75% oxygen for 5 days. After 5 days of hyp

SUBMITTER: Li N 

PROVIDER: S-EPMC3749514 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature