Increased mitochondrial oxidative phosphorylation in the liver is associated with obesity and insulin resistance.

ABSTRACT: Obesity is the result of excess energy intake relative to expenditure, however little is known about why some individuals are more prone to weight gain than others. Inbred strains of mice also vary in their susceptibility to obesity and therefore represent a valuable model to study the genetics and physiology of weight gain and its co-morbidities such as type 2 diabetes. C57BL/6J mice are susceptible to obesity and insulin resistance when fed an obesogenic diet, whereas A/J mice are resistant despite increased caloric intake. Analysis of B6- and A/J-derived chromosome substitution strains and congenic strains revealed a complex genetic and physiological basis for this phenotype. To improve our understanding of the molecular mechanisms underlying susceptibility to metabolic disease we analy

SUBMITTER: Buchner DA 

PROVIDER: S-EPMC3749733 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature