Role of IL28B gene polymorphism and cell-mediated immunity in spontaneous resolution of acute hepatitis C.

ABSTRACT:

Background

 A single-nucleotide polymorphism (SNP; rs12979860) near the IL28B gene has been associated with spontaneous and treatment-induced hepatitis C virus clearance. We investigated predictors of spontaneous disease resolution in a cohort of patients with acute hepatitis C (AHC), analyzing epidemiological, clinical and virological parameters together with IL28B.rs12979860 genotypes and cell-mediated immunity (CMI).

Methods

 Fifty-six symptomatic AHC patients were enrolled and followed prospectively. CMI was measured in 31 patients at multiple time points by interferon-γ enzyme-linked immunospot assay and was correlated to the IL28B.rs12979860 SNP.

Results

 Eighteen patients had a self-limiting AHC that was associated with female sex (P = .028), older age (P = .01

SUBMITTER: Spada E 

PROVIDER: S-EPMC3749747 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature