Medication adherence assessment: high accuracy of the new Ingestible Sensor System in kidney transplants.

ABSTRACT:

Background

This open-label single-arm exploratory study evaluated the accuracy of the Ingestible Sensor System (ISS), a novel technology for directly assessing the ingestion of oral medications and treatment adherence.

Methods

ISS consists of an ingestible event marker (IEM), a microsensor that becomes activated in gastric fluid, and an adhesive personal monitor (APM) that detects IEM activation. In this study, the IEM was combined to enteric-coated mycophenolate sodium (ECMPS). Twenty stable adult kidney transplants received IEM-ECMPS for a mean of 9.2 weeks totaling 1227 cumulative days.

Results

Eight patients prematurely discontinued treatment due to ECMPS gastrointestinal symptoms (n=2), skin intolerance to APM (n=2), and insufficient system usability (n=4). Rash

SUBMITTER: Eisenberger U 

PROVIDER: S-EPMC3749815 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature