Neonatal lupus: advances in understanding pathogenesis and identifying treatments of cardiac disease.

ABSTRACT:

Purpose of review

Cardiac manifestations of neonatal lupus include anti-SSA/Ro-SSB/La-mediated conduction system disease and endocardial/myocardial damage resulting in cardiomyopathy. This review will focus on recent data regarding updates on the proposed pathogenesis of disease, morbidity and mortality, and preventive and treatment therapies.

Recent findings

Evidence from animal models suggests that reactivity to the p200 region of the Ro52 protein, as well as antibody targeting of L-type calcium channels may be important in the development of cardiac neonatal lupus. In-vitro studies support a protective role of β-2 glycoprotein 1 (prevents anti-Ro binding to apoptotic cells) and pathologic roles of the urokinase-plasminogen activator/receptor system (leads to activation of

SUBMITTER: Izmirly PM 

PROVIDER: S-EPMC3749830 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature