Predictors of endoscopic inflammation in patients with ulcerative colitis in clinical remission.

ABSTRACT:

Background

Patients with ulcerative colitis (UC) who are in clinical remission may still have underlying endoscopic inflammation, which is associated with inferior clinical outcomes. The goal of this study was to determine the prevalence of active endoscopic disease, and factors associated with it, in patients with UC who are in clinical remission.

Methods

Prospective observational study in a single center. Patients with UC in clinical remission (by Simple Clinical Colitis Activity Index) were enrolled prospectively at the time of surveillance colonoscopy. Disease phenotype, endoscopic activity (Mayo subscore), and histologic score (Geboes) were recorded, and blood was drawn for peripheral blood biomarkers.

Results

Overall, 149 patients in clinical remission were pros

SUBMITTER: Rosenberg L 

PROVIDER: S-EPMC3749843 | biostudies-literature | 2013 Mar-Apr

REPOSITORIES: biostudies-literature