Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis.

ABSTRACT:

Purpose

Endothelial dysfunction is a primary contributor to sepsis-related organ dysfunction and death. In sepsis animal models, endothelial progenitor cells (EPC) have contributed to vascular repair. The role of endothelial progenitor cells as a biomarker for organ dysfunction is still unknown. We hypothesized that circulating numbers of endothelial progenitor cells would be associated with improved outcomes in sepsis.

Methods

Prospective, observational single-center cohort study in adult intensive care units at Grady Memorial Hospital, an affiliate of Emory University, from July 2007 through April 2009. Peripheral blood was obtained from 95 patients with sepsis, 37 intensive care unit controls, and 51 healthy controls, of whom only 86 patients with sepsis were used in the

SUBMITTER: Cribbs SK 

PROVIDER: S-EPMC3749881 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature